Ndị ọkà mmụta sayensị na Mahadum Hiroshima achọpụtala ihe ọhụrụ na broccoli na cabbages ndị ọzọ nwere ike inyere aka ịlụso ụdị ọrịa cancer ọgụ.
DIM, ma ọ bụ 3,3′-diindolylmethane, na-akpata ọnwụ cell a na-achịkwa na imegharị akụkụ cellular na yist fission. Amabeghị ma usoro mmebi nke DIM kpatara ka echekwara na mmadụ ugbu a.
"Anyị chọpụtara na ihe mejupụtara kemịkalụ DIM na-ebute ihe omume ọhụrụ nke na-emebi akpụkpọ ahụ nuklia na yist fission," Ueno, onye osote prọfesọ na Hiroshima Healthy Aging Research Center na Ụlọ Akwụkwọ Gụsịrị Akwụkwọ nke Integrated Life Sciences na Mahadum Hiroshima kwuru.
"Iguzosi ike n'ezi ihe nke mkpuchi nuklia dị mkpa maka ahụike mmadụ," Ueno na-ekwu. “Mgbanwe ndị na-akpata ntụpọ na akpụkpọ ahụ́ nuklia na-eme ka ịka nká dịkwuo elu. A na-agbajikwa ma na-arụzi membranes nuklia mgbe a na-akwaga mkpụrụ ndụ kansa.”
A na-akpọ akụkụ nke usoro nrụzi cell autophagy ma ọ bụ "iri onwe ya." Nke a bụ ụzọ mmebi nke akụkụ cellular, nke cell ga-eri akụkụ nke ime ya iji chekwaa ume ma kwalite usoro dị mkpa.
Ueno kwukwara na autophagy na-ejikọta ma ịka nká na ọrịa ndị metụtara afọ. Ọ bụrụ na mkpụrụ ndụ nwere nkwarụ, ọ na-anwụ site na usoro ọnwụ a haziri ahazi nke a na-akpọ apoptosis. Ọtụtụ ọgwụ cytotoxic anticancer na-arụ ọrụ site n'ịkwalite apoptosis, yabụ inwe ike ịchịkwa usoro a nwere ike inye aka idobe ma melite ahụike mmadụ, Ueno kwuru.
"Nsonaazụ anyị na-egosi na envelopu nuklia nwere ike ịbụ otu n'ime ihe mbụ DIM lekwasịrị anya," ka onye edemede akwụkwọ akụkọ Parvaneh Emami, bụ nwa akwụkwọ gụsịrị akwụkwọ na Ụlọ Akwụkwọ Gụsịrị Akwụkwọ na Integrated Life Sciences na Mahadum Hiroshima na-ekwu.
Nchọpụta a na-ewuli elu na akụkọ gara aga sitere n'aka otu ndị nyocha na Germany nke chọpụtara na ọnụ ọgụgụ dị elu nke DIM mụbara ogologo ndụ nke yist fission.
O nwere ike iyi ihe na-emegiderịta onwe ya na ihe na-akpata apoptosis nwere ike ịgbatị ogologo ndụ nke akụkụ ahụ, mana Emami kọwara na naanị DIM na-egosi na ọ na-ebute omume a n'ikewa mkpụrụ ndụ nke ukwuu, dị ka mkpụrụ ndụ kansa. Ọ bụrụ na ha anwụọ, organism nwere ike ịdị ogologo ndụ.
"Nchọpụta ndị e mere n'oge na-adịbeghị anya na ụmụ mmadụ na-egosi na DIM bụ ọgwụ nwere ike ịgwọ ọrịa cancer nke na-eme site n'ịkwalite apoptosis na ụdị ọrịa cancer dị iche iche, gụnyere ara, prostate, gastric and pancreatic cancer," Ueno kwuru.
“Nnyocha gosikwara na DIM na-ebute autophagy na mkpụrụ ndụ kansa. Otú ọ dị, mmetụta nke autophagy na nhazi tumo na ọganihu adịghị aghọta nke ọma. Ịghọta usoro apoptosis na autophagy site na DIM na yist fission nwere ike ịba uru maka nyocha banyere ọrịa cancer mmadụ na usoro nke ogologo ndụ."
Ndị nchọpụta ga-aga n'ihu na-amụ ọrụ DIM na yist fission.
"Anyị chọrọ ịghọta otú DIM si emebi fission yist nuclear membranes, nke nwere ike iduga mmepe nke ọgwụ mbụ iji gbuo mkpụrụ ndụ cancer," ka Emami kwuru.
"Anyị chọkwara ịghọta usoro nke DIM si ebute autophagy na yist fission, nke nwere ike inye aka n'ịghọta otu esi agbatị ndụ mmadụ."